FOXA2 is a pioneer
transcription factor that plays an important role in normal development and in
adult tissues. The Cancer Genome Atlas project identified FOXA2 as a
“significantly mutated gene” in endometrial cancer, with the majority of
mutations being loss-of-function defects. Epigenetic silencing of genes
associated with methylation of CpG-rich promoter regions is seen in cancers. We
sought to analyze the FOXA2promoter region for
methylation and to determine the relationship between methylation and mRNA and
protein expression.
https://epigenetics.expertconferences.org/events-list/epigenetics
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