Next-generation sequencing is poised to unleash
dramatic changes in every area of molecular biology. In the past few years,
chromatin immunoprecipitation (ChIP) on tiled microarrays (ChIP-chip) has been
an important tool for genome-wide mapping of DNA-binding proteins or histone
modifications. Now, ChIP followed by direct sequencing of DNA fragments
(ChIP-seq) offers superior data with less noise and higher resolution and is
likely to replace ChIP-chip in the near future. We will describe advantages of
this new technology and outline some of the issues in dealing with the data.
ChIP-seq generates considerably larger quantities of data and the most challenging
aspect for investigators will be computational and statistical analysis
necessary to uncover biological insights hidden in the data.
Go through to know more: https://epigenetics.expertconferences.org/events-list/bioinformatics-computational-analysis-of-epigenetics
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