During the last decades the study of male infertility & the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic investigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility & of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa & their effects on male fertility, embryonic development & ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications & RNAs.
A session "Epigenetics in reproductive health" going to be held at Vienna.
A session "Epigenetics in reproductive health" going to be held at Vienna.
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